Mercedes-Benz S450 W222

2017-2020Last updated: May 2026 · How this report is builtMay 2026

2017-2020 · 3.0L M256 inline-6 turbo (367 hp) with EQ Boost 48V mild hybrid

Mercedes-Benz S450 W222
Render © Car Checker

The W222 facelift S450 introduced the M256 turbocharged inline-six with 48V EQ Boost mild hybrid, replacing the outgoing M276 V6. The M256 is technologically advanced with an integrated starter-generator (ISG), electric auxiliary compressor (eBooster), and electric water pump, all running on the 48V system. Cabin refinement remains exceptional for the generation, and heavy depreciation on the used market means a flagship saloon is available for a fraction of its original price.· more· less

Advanced M256 inline-6 is smooth Exceptional refinement and comfort
48V hybrid system adds complexity AIRMATIC repairs remain expensive
Buy if: You want a refined flagship saloon with modern inline-6 efficiency and can budget for specialist maintenance and occasional 48V system attention.
Avoid if: You cannot absorb surprise repair bills in the €2,000-5,000 range or prefer an ownership experience without hybrid-system complexity.
Maintenance costs
€1,350 - €2,600/year
15,000 km/year
Fixed costs
€850-1,600
Risk buffer
€500-1,000
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Common Problems
Reliable platform, but flagship complexity means high repair costs when things do fail
The W222 S450 with the M256 inline-six is a well-regarded powertrain, and the engine itself is considered more reliable than the M278 V8 in the S500. However, the 48V mild hybrid system (ISG, eBooster, lithium-ion battery) adds a layer of complexity not present in earlier S-Class models. The AIRMATIC suspension is the most commonly reported failure point, as on all W222 variants. Proactive maintenance, particularly 9G-TRONIC fluid changes and air suspension inspections, significantly reduces the likelihood of expensive surprises. Budget for specialist diagnostics: this car requires Mercedes Star diagnostic equipment for most electrical and hybrid system issues.
Buying a used Mercedes-Benz S-Class? Check its history.
carVertical scans 1,000+ databases for damage, mileage rollbacks, theft records and ownership changes. Save 20% with code CARCHECKER.

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Pre-Purchase Inspection Checklist
General checks
Specific for this vehicle
Recalls and Technical Service Bulletins
Fuel rail and injector debris contamination (2018-2020 S450 with M256 engine) Critical - verify completed
Seatbelt warning system software fault (2017-2019 S-Class) Verify completed
Seatbelt pre-tensioner propellant issue (selected 2017-2018 production) Verify completed
Emergency call system (eCall) incorrect location data (2013-2017 production, OTA update) Verify completed
Side crash sensor connector affecting airbag deployment timing (2019-2020) Verify completed
The fuel rail and injector recall is particularly important for M256 engine cars, as debris from production can cause fuel leaks and fire risk. Contact a Mercedes-Benz dealer with the VIN to verify all recall work has been completed before purchase.
Warranty Status
Factory warranty (2 years) Expired on all used S450 W222 models
Rust perforation warranty (30 years) Still active on all W222 models
Extended warranty availability Available through Mercedes-Benz dealers, typically €1,500-3,000/year depending on age and coverage
All W222 S450 models (2017-2020) are outside their original 2-year factory warranty. Extended warranties through Mercedes-Benz or third-party providers are available but exclude wear items and may exclude certain suspension components. Verify exact coverage terms, particularly regarding AIRMATIC and 48V system components, before purchasing.

↔ Also consider

Mercedes-Benz S500 W222
Mercedes-Benz S500 W222 2013-2020
Pre-facelift V8 with M278 engine. More documented long-term issues including oil-wicking into ECU harness. Higher fixed costs due to V8 complexity.
BMW 750i G11
BMW 750i G11 2015-2022
Direct competitor with N63 V8. Air suspension issues on both. BMW extended the suspension warranty to 8 years due to complaints. Similar overall running costs.
Mercedes-Benz S350d W222
Mercedes-Benz S350d W222 2013-2020
Diesel variant on the same platform. OM642 V6 is well-proven but adds DPF and AdBlue concerns. Lower fuel costs offset by diesel-specific maintenance.
Mercedes-Benz S580 W223
Mercedes-Benz S580 W223 2021-present
Next-generation successor with M176 V8. More electronics and MBUX complexity. Still too new for comprehensive long-term reliability data.
Mercedes-Benz S500 W223
Mercedes-Benz S500 W223 2021-present
Successor with updated M256 inline-6. Same engine family but with revised ISG and updated software. AIRMATIC and 48V concerns carry over.

This report is for informational purposes only and does not constitute professional advice. Estimates may be inaccurate. Always have a qualified specialist inspect the vehicle before purchase. We accept no liability for decisions made based on this information.